Receptor Usage of a Novel Bat Lineage C Betacoronavirus Reveals Evolution of Middle East Respiratory Syndrome-Related Coronavirus Spike Proteins for Human Dipeptidyl Peptidase 4 Binding
Identifieur interne : 000834 ( Main/Exploration ); précédent : 000833; suivant : 000835Receptor Usage of a Novel Bat Lineage C Betacoronavirus Reveals Evolution of Middle East Respiratory Syndrome-Related Coronavirus Spike Proteins for Human Dipeptidyl Peptidase 4 Binding
Auteurs : Susanna K P. Lau [République populaire de Chine] ; Libiao Zhang [République populaire de Chine] ; Hayes K H. Luk [République populaire de Chine] ; Lifeng Xiong [République populaire de Chine] ; Xingwen Peng [République populaire de Chine] ; Kenneth S M. Li [République populaire de Chine] ; Xiangyang He [République populaire de Chine] ; Pyrear Su-Hui Zhao [République populaire de Chine] ; Rachel Y Y. Fan [République populaire de Chine] ; Antonio C P. Wong [République populaire de Chine] ; Syed Shakeel Ahmed [République populaire de Chine] ; Jian-Piao Cai [République populaire de Chine] ; Jasper F W. Chan [République populaire de Chine] ; Yinyan Sun [République populaire de Chine] ; Dongyan Jin [République populaire de Chine] ; Honglin Chen [République populaire de Chine] ; Terrence C K. Lau [République populaire de Chine] ; Raven K H. Kok [République populaire de Chine] ; Wenhui Li [République populaire de Chine] ; Kwok-Yung Yuen [République populaire de Chine] ; Patrick C Y. Woo [République populaire de Chine]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2018.
Descripteurs français
- KwdFr :
- Analyse de séquence d'ADN, Animaux, Cellules HEK293, Chiroptera, Dipeptidyl peptidase 4 (métabolisme), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (métabolisme), Humains, Liaison aux protéines, Phylogénie, Pénétration virale, Récepteurs viraux (métabolisme), Évolution moléculaire.
- MESH :
- génétique : Glycoprotéine de spicule des coronavirus.
- métabolisme : Dipeptidyl peptidase 4, Glycoprotéine de spicule des coronavirus, Récepteurs viraux.
- Analyse de séquence d'ADN, Animaux, Cellules HEK293, Chiroptera, Humains, Liaison aux protéines, Phylogénie, Pénétration virale, Évolution moléculaire.
English descriptors
- KwdEn :
- Animals, Betacoronavirus (classification), Betacoronavirus (genetics), Betacoronavirus (isolation & purification), Betacoronavirus (physiology), Chiroptera, Dipeptidyl Peptidase 4 (metabolism), Evolution, Molecular, HEK293 Cells, Humans, Phylogeny, Protein Binding, Receptors, Virus (metabolism), Sequence Analysis, DNA, Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (metabolism), Virus Internalization.
- MESH :
- chemical , genetics : Spike Glycoprotein, Coronavirus.
- chemical , metabolism : Dipeptidyl Peptidase 4, Receptors, Virus, Spike Glycoprotein, Coronavirus.
- classification : Betacoronavirus.
- genetics : Betacoronavirus.
- isolation & purification : Betacoronavirus.
- physiology : Betacoronavirus.
- Animals, Chiroptera, Evolution, Molecular, HEK293 Cells, Humans, Phylogeny, Protein Binding, Sequence Analysis, DNA, Virus Internalization.
Abstract
The discovery of Hp-BatCoV HKU25 bridges the evolutionary gap between MERS-CoV and existing bat viruses, and suggests that bat viruses may have evolved to generate MERS-CoV through modulation of the spike protein for binding to hDPP4.
Url:
DOI: 10.1093/infdis/jiy018
PubMed: 29346682
PubMed Central: 7107427
Affiliations:
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Le document en format XML
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Chan</name><affiliation wicri:level="1"><nlm:aff id="AF0001">State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Microbiology The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0003">Carol Yu Centre for Infection The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Carol Yu Centre for Infection The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0004">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Yinyan" sort="Sun, Yinyan" uniqKey="Sun Y" first="Yinyan" last="Sun">Yinyan Sun</name><affiliation wicri:level="3"><nlm:aff id="AF0006">National Institute of Biological Sciences, Zhongguancun Life Science Park, Changping, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Institute of Biological Sciences, Zhongguancun Life Science Park, Changping, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jin, Dongyan" sort="Jin, Dongyan" uniqKey="Jin D" first="Dongyan" last="Jin">Dongyan Jin</name><affiliation wicri:level="1"><nlm:aff id="AF0007">School of Biomedical Sciences, The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Biomedical Sciences, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name><affiliation wicri:level="1"><nlm:aff id="AF0001">State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Microbiology The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0003">Carol Yu Centre for Infection The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Carol Yu Centre for Infection The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0004">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Lau, Terrence C K" sort="Lau, Terrence C K" uniqKey="Lau T" first="Terrence C K" last="Lau">Terrence C K. Lau</name><affiliation wicri:level="1"><nlm:aff id="AF0008">Department of Biomedical Sciences, City University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biomedical Sciences, City University of Hong Kong</wicri:regionArea><wicri:noRegion>City University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Kok, Raven K H" sort="Kok, Raven K H" uniqKey="Kok R" first="Raven K H" last="Kok">Raven K H. 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Woo</name><affiliation wicri:level="1"><nlm:aff id="AF0001">State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Microbiology The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0003">Carol Yu Centre for Infection The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Carol Yu Centre for Infection The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0004">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29346682</idno><idno type="pmc">7107427</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7107427</idno><idno type="RBID">PMC:7107427</idno><idno type="doi">10.1093/infdis/jiy018</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000E31</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E31</idno><idno type="wicri:Area/Pmc/Curation">000E31</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E31</idno><idno type="wicri:Area/Pmc/Checkpoint">000483</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000483</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:29346682</idno><idno type="wicri:Area/PubMed/Corpus">000A18</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A18</idno><idno type="wicri:Area/PubMed/Curation">000A18</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A18</idno><idno type="wicri:Area/PubMed/Checkpoint">000789</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000789</idno><idno type="wicri:Area/Ncbi/Merge">001D13</idno><idno type="wicri:Area/Ncbi/Curation">001D13</idno><idno type="wicri:Area/Ncbi/Checkpoint">001D13</idno><idno type="wicri:doubleKey">0022-1899:2018:Lau S:receptor:usage:of</idno><idno type="wicri:Area/Main/Merge">000837</idno><idno type="wicri:Area/Main/Curation">000834</idno><idno type="wicri:Area/Main/Exploration">000834</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Receptor Usage of a Novel Bat Lineage C Betacoronavirus Reveals Evolution of Middle East Respiratory Syndrome-Related Coronavirus Spike Proteins for Human Dipeptidyl Peptidase 4 Binding</title><author><name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K P" last="Lau">Susanna K P. Lau</name><affiliation wicri:level="1"><nlm:aff id="AF0001">State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Microbiology The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0003">Carol Yu Centre for Infection The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Carol Yu Centre for Infection The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0004">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Libiao" sort="Zhang, Libiao" uniqKey="Zhang L" first="Libiao" last="Zhang">Libiao Zhang</name><affiliation wicri:level="1"><nlm:aff id="AF0005">Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province</wicri:regionArea><wicri:noRegion>Guangdong Province</wicri:noRegion></affiliation></author><author><name sortKey="Luk, Hayes K H" sort="Luk, Hayes K H" uniqKey="Luk H" first="Hayes K H" last="Luk">Hayes K H. Luk</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Microbiology The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Xiong, Lifeng" sort="Xiong, Lifeng" uniqKey="Xiong L" first="Lifeng" last="Xiong">Lifeng Xiong</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Microbiology The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Peng, Xingwen" sort="Peng, Xingwen" uniqKey="Peng X" first="Xingwen" last="Peng">Xingwen Peng</name><affiliation wicri:level="1"><nlm:aff id="AF0005">Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province</wicri:regionArea><wicri:noRegion>Guangdong Province</wicri:noRegion></affiliation></author><author><name sortKey="Li, Kenneth S M" sort="Li, Kenneth S M" uniqKey="Li K" first="Kenneth S M" last="Li">Kenneth S M. Li</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Microbiology The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="He, Xiangyang" sort="He, Xiangyang" uniqKey="He X" first="Xiangyang" last="He">Xiangyang He</name><affiliation wicri:level="1"><nlm:aff id="AF0005">Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province</wicri:regionArea><wicri:noRegion>Guangdong Province</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Pyrear Su Hui" sort="Zhao, Pyrear Su Hui" uniqKey="Zhao P" first="Pyrear Su-Hui" last="Zhao">Pyrear Su-Hui Zhao</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Microbiology The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Fan, Rachel Y Y" sort="Fan, Rachel Y Y" uniqKey="Fan R" first="Rachel Y Y" last="Fan">Rachel Y Y. Fan</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Microbiology The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Antonio C P" sort="Wong, Antonio C P" uniqKey="Wong A" first="Antonio C P" last="Wong">Antonio C P. Wong</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Microbiology The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Ahmed, Syed Shakeel" sort="Ahmed, Syed Shakeel" uniqKey="Ahmed S" first="Syed Shakeel" last="Ahmed">Syed Shakeel Ahmed</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Microbiology The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Cai, Jian Piao" sort="Cai, Jian Piao" uniqKey="Cai J" first="Jian-Piao" last="Cai">Jian-Piao Cai</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Microbiology The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Chan, Jasper F W" sort="Chan, Jasper F W" uniqKey="Chan J" first="Jasper F W" last="Chan">Jasper F W. Chan</name><affiliation wicri:level="1"><nlm:aff id="AF0001">State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Microbiology The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0003">Carol Yu Centre for Infection The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Carol Yu Centre for Infection The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0004">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Yinyan" sort="Sun, Yinyan" uniqKey="Sun Y" first="Yinyan" last="Sun">Yinyan Sun</name><affiliation wicri:level="3"><nlm:aff id="AF0006">National Institute of Biological Sciences, Zhongguancun Life Science Park, Changping, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Institute of Biological Sciences, Zhongguancun Life Science Park, Changping, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jin, Dongyan" sort="Jin, Dongyan" uniqKey="Jin D" first="Dongyan" last="Jin">Dongyan Jin</name><affiliation wicri:level="1"><nlm:aff id="AF0007">School of Biomedical Sciences, The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Biomedical Sciences, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name><affiliation wicri:level="1"><nlm:aff id="AF0001">State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Microbiology The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0003">Carol Yu Centre for Infection The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Carol Yu Centre for Infection The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0004">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Lau, Terrence C K" sort="Lau, Terrence C K" uniqKey="Lau T" first="Terrence C K" last="Lau">Terrence C K. Lau</name><affiliation wicri:level="1"><nlm:aff id="AF0008">Department of Biomedical Sciences, City University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biomedical Sciences, City University of Hong Kong</wicri:regionArea><wicri:noRegion>City University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Kok, Raven K H" sort="Kok, Raven K H" uniqKey="Kok R" first="Raven K H" last="Kok">Raven K H. Kok</name><affiliation wicri:level="1"><nlm:aff id="AF0001">State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Microbiology The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0003">Carol Yu Centre for Infection The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Carol Yu Centre for Infection The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0004">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Li, Wenhui" sort="Li, Wenhui" uniqKey="Li W" first="Wenhui" last="Li">Wenhui Li</name><affiliation wicri:level="3"><nlm:aff id="AF0006">National Institute of Biological Sciences, Zhongguancun Life Science Park, Changping, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Institute of Biological Sciences, Zhongguancun Life Science Park, Changping, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation wicri:level="1"><nlm:aff id="AF0001">State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Microbiology The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0003">Carol Yu Centre for Infection The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Carol Yu Centre for Infection The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0004">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C Y" last="Woo">Patrick C Y. Woo</name><affiliation wicri:level="1"><nlm:aff id="AF0001">State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Microbiology The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0003">Carol Yu Centre for Infection The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Carol Yu Centre for Infection The University of Hong Kong</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0004">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Betacoronavirus (classification)</term><term>Betacoronavirus (genetics)</term><term>Betacoronavirus (isolation & purification)</term><term>Betacoronavirus (physiology)</term><term>Chiroptera</term><term>Dipeptidyl Peptidase 4 (metabolism)</term><term>Evolution, Molecular</term><term>HEK293 Cells</term><term>Humans</term><term>Phylogeny</term><term>Protein Binding</term><term>Receptors, Virus (metabolism)</term><term>Sequence Analysis, DNA</term><term>Spike Glycoprotein, Coronavirus (genetics)</term><term>Spike Glycoprotein, Coronavirus (metabolism)</term><term>Virus Internalization</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de séquence d'ADN</term><term>Animaux</term><term>Cellules HEK293</term><term>Chiroptera</term><term>Dipeptidyl peptidase 4 (métabolisme)</term><term>Glycoprotéine de spicule des coronavirus (génétique)</term><term>Glycoprotéine de spicule des coronavirus (métabolisme)</term><term>Humains</term><term>Liaison aux protéines</term><term>Phylogénie</term><term>Pénétration virale</term><term>Récepteurs viraux (métabolisme)</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dipeptidyl Peptidase 4</term><term>Receptors, Virus</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine de spicule des coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Dipeptidyl peptidase 4</term><term>Glycoprotéine de spicule des coronavirus</term><term>Récepteurs viraux</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chiroptera</term><term>Evolution, Molecular</term><term>HEK293 Cells</term><term>Humans</term><term>Phylogeny</term><term>Protein Binding</term><term>Sequence Analysis, DNA</term><term>Virus Internalization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence d'ADN</term><term>Animaux</term><term>Cellules HEK293</term><term>Chiroptera</term><term>Humains</term><term>Liaison aux protéines</term><term>Phylogénie</term><term>Pénétration virale</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The discovery of Hp-BatCoV HKU25 bridges the evolutionary gap between MERS-CoV and existing bat viruses, and suggests that bat viruses may have evolved to generate MERS-CoV through modulation of the spike protein for binding to hDPP4.</p></div></front><back><div1 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Lau</name></noRegion><name sortKey="Ahmed, Syed Shakeel" sort="Ahmed, Syed Shakeel" uniqKey="Ahmed S" first="Syed Shakeel" last="Ahmed">Syed Shakeel Ahmed</name><name sortKey="Cai, Jian Piao" sort="Cai, Jian Piao" uniqKey="Cai J" first="Jian-Piao" last="Cai">Jian-Piao Cai</name><name sortKey="Chan, Jasper F W" sort="Chan, Jasper F W" uniqKey="Chan J" first="Jasper F W" last="Chan">Jasper F W. Chan</name><name sortKey="Chan, Jasper F W" sort="Chan, Jasper F W" uniqKey="Chan J" first="Jasper F W" last="Chan">Jasper F W. Chan</name><name sortKey="Chan, Jasper F W" sort="Chan, Jasper F W" uniqKey="Chan J" first="Jasper F W" last="Chan">Jasper F W. Chan</name><name sortKey="Chan, Jasper F W" sort="Chan, Jasper F W" uniqKey="Chan J" first="Jasper F W" last="Chan">Jasper F W. Chan</name><name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name><name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name><name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name><name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name><name sortKey="Fan, Rachel Y Y" sort="Fan, Rachel Y Y" uniqKey="Fan R" first="Rachel Y Y" last="Fan">Rachel Y Y. Fan</name><name sortKey="He, Xiangyang" sort="He, Xiangyang" uniqKey="He X" first="Xiangyang" last="He">Xiangyang He</name><name sortKey="Jin, Dongyan" sort="Jin, Dongyan" uniqKey="Jin D" first="Dongyan" last="Jin">Dongyan Jin</name><name sortKey="Kok, Raven K H" sort="Kok, Raven K H" uniqKey="Kok R" first="Raven K H" last="Kok">Raven K H. Kok</name><name sortKey="Kok, Raven K H" sort="Kok, Raven K H" uniqKey="Kok R" first="Raven K H" last="Kok">Raven K H. Kok</name><name sortKey="Kok, Raven K H" sort="Kok, Raven K H" uniqKey="Kok R" first="Raven K H" last="Kok">Raven K H. Kok</name><name sortKey="Kok, Raven K H" sort="Kok, Raven K H" uniqKey="Kok R" first="Raven K H" last="Kok">Raven K H. Kok</name><name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K P" last="Lau">Susanna K P. Lau</name><name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K P" last="Lau">Susanna K P. Lau</name><name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K P" last="Lau">Susanna K P. Lau</name><name sortKey="Lau, Terrence C K" sort="Lau, Terrence C K" uniqKey="Lau T" first="Terrence C K" last="Lau">Terrence C K. Lau</name><name sortKey="Li, Kenneth S M" sort="Li, Kenneth S M" uniqKey="Li K" first="Kenneth S M" last="Li">Kenneth S M. Li</name><name sortKey="Li, Wenhui" sort="Li, Wenhui" uniqKey="Li W" first="Wenhui" last="Li">Wenhui Li</name><name sortKey="Luk, Hayes K H" sort="Luk, Hayes K H" uniqKey="Luk H" first="Hayes K H" last="Luk">Hayes K H. Luk</name><name sortKey="Peng, Xingwen" sort="Peng, Xingwen" uniqKey="Peng X" first="Xingwen" last="Peng">Xingwen Peng</name><name sortKey="Sun, Yinyan" sort="Sun, Yinyan" uniqKey="Sun Y" first="Yinyan" last="Sun">Yinyan Sun</name><name sortKey="Wong, Antonio C P" sort="Wong, Antonio C P" uniqKey="Wong A" first="Antonio C P" last="Wong">Antonio C P. Wong</name><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C Y" last="Woo">Patrick C Y. Woo</name><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C Y" last="Woo">Patrick C Y. Woo</name><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C Y" last="Woo">Patrick C Y. Woo</name><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C Y" last="Woo">Patrick C Y. Woo</name><name sortKey="Xiong, Lifeng" sort="Xiong, Lifeng" uniqKey="Xiong L" first="Lifeng" last="Xiong">Lifeng Xiong</name><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><name sortKey="Zhang, Libiao" sort="Zhang, Libiao" uniqKey="Zhang L" first="Libiao" last="Zhang">Libiao Zhang</name><name sortKey="Zhao, Pyrear Su Hui" sort="Zhao, Pyrear Su Hui" uniqKey="Zhao P" first="Pyrear Su-Hui" last="Zhao">Pyrear Su-Hui Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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